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<title>Crucell N.V.  - Pressemeldinger</title>
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<flastmod date="2010-03-02T16:24:46 CET"/>
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<press_release id="1072171" language="en" type="1">
<published date="2006-08-29T22:00:00 CET"/>
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<category id="5" label="English" keywords="language"/>

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<headline><![CDATA[Berna Biotech Ltd (SWX: BBIN) announces half-year results 2006]]></headline>
<ingress><![CDATA[]]></ingress>
<main><![CDATA[<div class="hugin"><b class="hugin">Organization</b></div>
<div class="hugin">On December 15, 2005, Crucell N.V. launched a Public Exchange Offer to Berna Shareholders. For details see the Offer Prospectus dated December 15, 2005.</div>
<div class="hugin">&nbsp;</div>
<div class="hugin">Crucell (Euronext, NASDAQ: CRXL; Swiss Exchange: SW CRX) is a biotechnology company focused on developing vaccines and antibodies that prevent and treat infectious diseases, including Ebola, influenza, malaria, West Nile virus and rabies. Crucell's products are based on its PER.C6® production technology. Crucell is headquartered in Leiden, The Netherlands. For more information, please visit <a href="http://www.crucell.com" class="hugin">www.crucell.com</a>.</div>
<div class="hugin">&nbsp;</div>
<div class="hugin">The Berna Shareholders' accepted Crucell's offer on the extraordinary Shareholders' meeting on January 11, 2006. After expiration of the acceptance period on February 8, 2006, 96.56% of the Berna Biotech shares have been tendered. On February 22, 2006 was the first trading day of Crucell shares on the SWX Swiss Exchange (SWX: CR). Currently Crucell NV holds more than 98% of the Berna Biotech shares.</div>
<div class="hugin">&nbsp;</div>
<div class="hugin">Crucell NV will pursue a squeeze-out of the remaining minority shareholdings and to delist Berna Biotech AG in connection therewith.</div>
<div class="hugin"><b class="hugin"></b>&nbsp;</div>
<div class="hugin">In January 2006 Kenta AG, Switzerland was founded. Berna Biotech contributed TCHF 5 250 in non-current assets, which represents 36.74% of the share capital. Kenta AG is treated as an investment in an associate and accounted for using the equity method.</div>
<div class="hugin">&nbsp;</div>
<div class="hugin">In April 2006 the Group sold its shares in the Rhein Biotech GmbH, Germany and in May 2006 the Group sold its shares in the Dr. E. Gräub AG, Switzerland including also the Veterinär AG.</div>
<div class="hugin">&nbsp;</div>
<div class="hugin"><b class="hugin">Activities</b></div>
<div class="hugin">Total revenue of core business vaccines overall increased by 11% on a comparable basis. Travel vaccines sales increased by 49% driven by the geographic expansion and market share gains in Europe of Epaxal®. The Hep B and pediatric franchise shows a double digit decrease of 20% due to the divestments in 2005.The loss from operations (EBIT) increased significantly due to extraordinary expenses lower gross profit. Loss for the period is 36.3 million CHF. The equity ratio for the equity attributable to equity holders is 68%. Cash and cash equivalents at the end of the period of 149 million CHF.</div>
<div class="hugin"><b class="hugin"></b>&nbsp;</div>
<div class="hugin">In March 2006 the Korea Food and Drug Administration (KFDA) has awarded licensure to Quinvaxem(TM), a fully liquid pentavalent vaccine co-developed with Chiron Corporation and produced in Korea. </div>
<div class="hugin">&nbsp;</div>
<div align="justify" class="hugin">In July it has been announced that it has decided to suspend further clinical development of Aerugen®, its vaccine candidate for the prevention of Pseudomonas aeruginosa infection in cystic fibrosis (CF) patients. </div>
<div class="hugin">&nbsp;</div>
<div class="hugin">It is foreseen before the end of the year that Berna Biotech will have delisted its shares from the SWX Swiss Exchange. <br class="hugin"><br class="hugin"></div>
<div class="hugin">&nbsp;</div>
<div class="hugin"><b class="hugin"><i class="hugin">Berna Biotech</i></b><i class="hugin"> Ltd (Swiss Exchange: BBIN) develops, produces and markets vaccines and immunotherapeutics for private and public markets world-wide.</i></div>
<div class="hugin"><i class="hugin">Headquartered in Berne, Switzerland, with subsidiaries in Europe and Korea, Berna is a fully integrated vaccines company, employing around 700 people. </i></div>
<div class="hugin"><i class="hugin">Berna Biotech's range of novel and validated proprietary technology platforms supports a strong product portfolio. The company markets its core vaccine products in the field of hepatitis B/paediatric, respiratory and travel vaccines and has a focused development pipeline. Development is supported through alliances with academic and commercial partners.</i></div>
<div align="left" class="hugin"><em class="hugin">Further information on Berna: </em><a href="http://www.bernabiotech.com/" class="hugin"><em class="hugin">www.bernabiotech.com</em></a></div>
<div class="hugin"><b class="hugin"></b>&nbsp;</div>
<div class="hugin"><b class="hugin">Please address any questions to:</b></div>
<div class="hugin"><b class="hugin">Crucell N.V.</b></div>
<div class="hugin">Paul Vermeij</div>
<div class="hugin">Director Investor Relations and</div>
<div class="hugin">Corporate Communications</div>
<div class="hugin">Tel. +31 (0)71 524 8718</div>
<div class="hugin">p.vermeij@crucell.com</div><br class="hugin">
<div class="hugin">&nbsp;</div>
<div class="hugin"><b class="hugin">Berna Biotech Group</b></div>
<div class="hugin"><b class="hugin"></b>&nbsp;</div>
<div class="hugin"><b class="hugin">Key Figures</b></div>
<div class="hugin">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </div>
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<div class="hugin"><i class="hugin">in CHF '000 </i></div></td>
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<div class="hugin">June 30, 2006</div></td>
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<div class="hugin">June 30, 2005</div></td></tr>
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<div class="hugin">Revenue</div></td>
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<div align="right" class="hugin">50 963</div></td>
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<div align="right" class="hugin">65 997</div></td></tr>
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<div class="hugin">Revenue "Core Business Vaccinces"</div></td>
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<div align="right" class="hugin">41 418</div></td>
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<div align="right" class="hugin">37 198</div></td></tr>
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<div class="hugin">Cost of sales</div></td>
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<div align="right" class="hugin">-45 016</div></td>
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<div align="right" class="hugin">-45 646</div></td></tr>
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<div class="hugin">Gross Profit</div></td>
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<div align="right" class="hugin">5 947</div></td>
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<div align="right" class="hugin">20 351</div></td></tr>
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<div class="hugin">Loss from operations (EBIT)</div></td>
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<div align="right" class="hugin">-33 753</div></td>
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<div align="right" class="hugin">-13 916</div></td></tr>
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<div class="hugin">Loss for the period attributable to equity holders</div></td>
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<div align="right" class="hugin">-36 293</div></td>
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<div align="right" class="hugin">-11 437</div></td></tr>
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<div class="hugin"><i class="hugin">in CHF '000 (except Number of employees)</i></div></td>
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<div align="right" class="hugin">June 30, 2006</div></td>
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<div align="right" class="hugin">Dec. 31, 2005</div></td></tr>
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<div class="hugin">Cash and cash equivalents </div></td>
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<div align="right" class="hugin">148 970</div></td>
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<div align="right" class="hugin">157 574</div></td></tr>
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<div class="hugin">Total assets</div></td>
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<div align="right" class="hugin">435 471</div></td>
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<div align="right" class="hugin">449 433</div></td></tr>
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<div class="hugin">Total equity</div></td>
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<div align="right" class="hugin">307 612</div></td>
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<div align="right" class="hugin">327 004</div></td></tr>
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<div class="hugin">Number of employees</div></td>
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<div align="right" class="hugin">652</div></td>
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<div align="right" class="hugin">715</div></td></tr></table>
<div class="hugin">&nbsp;</div>
<div class="hugin">&nbsp;</div>
<div class="hugin">&nbsp;</div>
<div class="hugin">The consolidated interim financial statements 2006 are attached, and also available on: www.bernabiotech.com<i class="hugin"></i></div>
<div class="hugin"><i class="hugin"></i>&nbsp;</div>
<div class="hugin"><i class="hugin"></i>&nbsp;</div>]]></main>
<footer><![CDATA[]]></footer>
 <files>

<file id="183305" format="pdf" type="Regular Attachment">
<file_headline>Press Release_PDF</file_headline>
<location href="http://hugin.info/132631/R/1072171/183305.pdf"/>
</file>



<file id="183306" format="pdf" type="Regular Attachment">
<file_headline>Consolidated Interim Figures</file_headline>
<location href="http://hugin.info/132631/R/1072171/183306.pdf"/>
</file>

 </files>
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